Publications

A biofilm-tropic Pseudomonas aeruginosa bacteriophage uses the exopolysaccharide Psl as receptor.

Walton, B., Abbondante S., Marshall M. E., Dobruchowska J. M., Alvi A., Gallagher L. A., Vallikat N., Zhang Z., Wozniak D. J., Yu E. W., Boons G.-J., Pearlman E., Rietsch, A.

eLife. 2025. 13:RP102352. doi: 10.7554/eLife.102352.1

The Pseudomonas aeruginosa T3SS can contribute to traversal of an in situ epithelial multilayer independently of the T3SS needle.

Jedel, E., Schator, D., Kumar, N.G., Sullivan, A.B., Rietsch, A., Evans, D.J., Fleiszig, S.M.J.

mBio. 2025. 9;16(4):e0026625. doi: 10.1128/mbio.00266-25.

A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection.

K. Schelde, J. Rosenjack, C. Sonneborn, A. Jafri, M. Kavran, S. Brumbaugh, A. Rietsch, R.J. Darrah, C.A. Hodges, C.A. Flask, T.J. Kelley, M.L. Drumm

Laboratory Animals. 2023. doi: 10.1177/00236772231175553

NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.

Minns, M., Liboro, K., Lima, T.S., Abbondante, S., Miller, B.A., Marshall, M.E., Tran-Chau, J. Roistacher, A., Rietsch, A., Dubyak, G.R., and Pearlman, E.

Nature Communications. 2023. 14(1):5832. doi: 10.1038/s41467-023-41391-7

PopB-PcrV Interactions are Essential for Pore Formation in the Pseudomonas aeruginosa Type III Secretion System Translocon.

Kundracik E.C., Trichka, J., Díaz Aponte, J.E., Roistacher, A., and Rietsch A.

mBio. 2022 Sep 26;e0238122. doi:10.1128/mbio.02381-22

The PopN Gate-keeper Complex Acts on the ATPase PscN to Regulate the T3SS Secretion Switch from Early to Middle Substrates in Pseudomonas aeruginosa.

Tuan-Dung Ngo, Caroline Perdu, Bakhos Jneid, Michel Ragno, Julia Novion Ducassou, Alexandra Kraut, Yohann Couté, Charles Stopford, Ina Attrée, Arne Rietsch, Eric Faudry

Journal of Molecular Biology. 2020. 432(24):166690

Cell-type specific hypertranslocation of effectors by the Pseudomonas aeruginosa type III secretion system.

Armentrout, E.I., Kundracik E.C., and Rietsch A.

Mol Microbiol. 2021. 115(2):305-319. doi: 10.1111/mmi.14617

The structure of the Type III Secretion System export gate with CdsO, an ATPase lever arm.

Jensen, J.L., Yamini, S., Rietsch, A., and Spiller, B.W.

PLoS Pathogens. 2020. 16(10):e1008923

RNase E promotes expression of type III secretion system genes in Pseudomonas aeruginosa.

Josh. S. Sharp, Arne Rietsch, Simon L. Dove

Journal of Bacteriology. 2019. 201(22). pii: e00336-19.

Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.

Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A.

Cell host & microbe. 2017; 21(5):611-618.e5.

The Type III Secretion Translocation Pore Senses Host Cell Contact.

Armentrout EI, Rietsch A.

PLoS pathogens. 2016; 12(3):e1005530.

Fueling type III secretion.

Lee PC, Rietsch A.

Trends in microbiology. 2015; 23(5):296-300.

Control of type III secretion activity and substrate specificity by the cytoplasmic regulator PcrG.

Lee PC, Zmina SE, Stopford CM, Toska J, Rietsch A.

Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(19):E2027-36.

Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates.

Toska J, Sun Y, Carbonell DA, Foster AN, Jacobs MR, Pearlman E, Rietsch A.

PloS one. 2014; 9(1):e86829.

Dimerization of the Pseudomonas aeruginosa translocator chaperone PcrH is required for stability, not function.

Tomalka AG, Zmina SE, Stopford CM, Rietsch A.

Journal of bacteriology. 2013; 195(21):4836-43.

Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers.

Karthikeyan RS, Priya JL, Leal SM Jr, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P.

PloS one. 2013; 8(6):e64867.

Host defense at the ocular surface.

Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A.

International reviews of immunology. 2013; 32(1):4-18.

A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function.

Tomalka AG, Stopford CM, Lee PC, Rietsch A.

Molecular microbiology. 2012; 86(6):1464-81.

Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.

Karmakar M, Sun Y, Hise AG, Rietsch A, Pearlman E.

Journal of immunology (Baltimore, Md. : 1950). 2012; 189(9):4231-5.

ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.

Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E.

Journal of immunology (Baltimore, Md. : 1950). 2012; 188(4):1884-95.

TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.

Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E.

Journal of immunology (Baltimore, Md. : 1950). 2010; 185(7):4272-83.

Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV.

Lee PC, Stopford CM, Svenson AG, Rietsch A.

Molecular microbiology. 2010; 75(4):924-41.

ExoS controls the cell contact-mediated switch to effector secretion in Pseudomonas aeruginosa.

Cisz M, Lee PC, Rietsch A.

Journal of bacteriology. 2008; 190(8):2726-38.

Rietsch Lab

Publications